Please use this identifier to cite or link to this item: http://archive.cmb.ac.lk:8080/xmlui/handle/70130/7317
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dc.contributor.authorWeerakoon, W.A.S.S.-
dc.contributor.authorPerera, P.K.-
dc.contributor.authorSamarasinghe, K.-
dc.contributor.authorGunasekera, D.-
dc.contributor.authorSuresh, T.S.-
dc.date.accessioned2024-09-03T06:17:34Z-
dc.date.available2024-09-03T06:17:34Z-
dc.date.issued2020-
dc.identifier.citationWeerakoon, W.A.S.S., Perera, P.K., Samarasinghe, K., Gunasekera, D., and Suresh, T.S. (2020). Acute and Subchronic Oral Safety Profiles of the Sudarshana Suspension. Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2020/2891058en_US
dc.identifier.issn1741-427X-
dc.identifier.urihttps://doi.org/10.1155/2020/2891058-
dc.identifier.urihttp://archive.cmb.ac.lk:8080/xmlui/handle/70130/7317-
dc.description.abstractSudarshana powder (SP) is an Ayurvedic preparation, which contains 53 herbal ingredients along with 50% of Andrographis paniculata and is clinically used with bees honey. +is study was aimed to determine the safety pro4le of the SP, and its novel preparation Sudarshana suspension (SS) on male Wistar rats and tolerance studies were conducted for healthy adult volunteers. Acute and subacute toxicity studies of the SS and hot water extract of SP were assessed in Wistar rats by observing the general behavior, analyzing biochemical and haematological parameters, and pathological observation. Healthy consented adult volunteers (n � 35) of either sex were selected, and tolerance studies of SS were tested by measuring the biochemical and haematological parameters. +ere were no signi4cant (p>0.05) changes observed in the treated animals with SS and hot water extract of SP compared with control in body weights, food intake, and water consumption as well as the biochemical and haematological parameters. Histopathological studies revealed no signi4cant (p>0.05) changes in the liver, heart, and kidney tissues. +e experimental results suggest that novel formulation SS was potentially safe for chronic administration in rats, and no signi4cant di8erences (p>0.05) were observed in tested parameters on day 3 and day 8 when compared to the day 0 (baseline) values in healthy volunteers. Healthy volunteers did not report any adverse e8ects or any other complications during the treatment period and the follow-up period. +erefore, it can be concluded that the novel preparation Sudarshana suspension does not cause any signi4cant toxic e8ects on the blood parameters in animal and human models.en_US
dc.language.isoenen_US
dc.publisherEvidence-Based Complementary and Alternative Medicineen_US
dc.subjectSudarshana Suspensionen_US
dc.subjectOral Safetyen_US
dc.titleAcute and Subchronic Oral Safety Profiles of the Sudarshana Suspensionen_US
dc.typeArticleen_US
Appears in Collections:Department of Ayurveda Pharmacology, Pharmaceutics and Community Medicine

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