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http://archive.cmb.ac.lk:8080/xmlui/handle/70130/6060| Title: | Cellulose Supported Magnetic Nanohybrids: Synthesis, Physicomagnetic Properties and Biomedical Applications-A Review |
| Authors: | Mohamed Abdul Cader Mohamed Haniffa Khadija Munawar Ching Yern Chee Sumit Pramanik Ahmed Halilu Hazlee Azil Illias Muhammad Rizwan Senthilnithy, Rajendram Mahanama, K.R.R Tripathy, Ashis Mohd Fahmi Azman |
| Keywords: | Cancer therapy Drug delivery Enzyme immobilization Folate-conjugate MRI Magneto-responsive cellulose |
| Issue Date: | 2021 |
| Publisher: | Elsevier |
| Citation: | Mohamed Abdul Cader Mohamed Haniffa, Khadija Munawar, Ching Yern Chee, Sumit Pramanik, Ahmed Halilu, Hazlee Azil Illias, Muhammad Rizwan, Rajendram Senthilnithy, Kariyawasam Ranaweerage Ranjith Mahanama, Ashis Tripathy, Mohd Fahmi Azman, Cellulose supported magnetic nanohybrids: Synthesis, physicomagnetic properties and biomedical applications-A review, Carbohydrate Polymers, Volume 267, 2021, 118136, ISSN 0144-8617, https://doi.org/10.1016/j.carbpol.2021.118136. (https://www.sciencedirect.com/science/article/pii/S0144861721005233) Abstract: Cellulose and its forms are widely used in biomedical applications due to their biocompatibility, biodegradability and lack of cytotoxicity. It provides ample opportunities for the functionalization of supported magnetic nanohybrids (CSMNs). Because of the abundance of surface hydroxyl groups, they are surface tunable in either homogeneous or heterogeneous solvents and thus act as a substrate or template for the CSMNs' development. The present review emphasizes on the synthesis of various CSMNs, their physicomagnetic properties, and potential applications such as stimuli-responsive drug delivery systems, MRI, enzyme encapsulation, nucleic acid extraction, wound healing and tissue engineering. The impact of CSMNs on cytotoxicity, magnetic hyperthermia, and folate-conjugates is highlighted in particular, based on their structures, cell viability, and stability. Finally, the review also discussed the challenges and prospects of CSMNs' development. This review is expected to provide CSMNs' development roadmap in the context of 21st-century demands for biomedical therapeutics. Keywords: Magneto-responsive cellulose; Cancer therapy; Drug delivery; MRI; Enzyme immobilization; Folate-conjugate |
| Abstract: | Cellulose and its forms are widely used in biomedical applications due to their biocompatibility, biodegradability and lack of cytotoxicity. It provides ample opportunities for the functionalization of supported magnetic nanohybrids (CSMNs). Because of the abundance of surface hydroxyl groups, they are surface tunable in either homogeneous or heterogeneous solvents and thus act as a substrate or template for the CSMNs' development. The present review emphasizes on the synthesis of various CSMNs, their physicomagnetic properties, and potential applications such as stimuli-responsive drug delivery systems, MRI, enzyme encapsulation, nucleic acid extraction, wound healing and tissue engineering. The impact of CSMNs on cytotoxicity, magnetic hyperthermia, and folate-conjugates is highlighted in particular, based on their structures, cell viability, and stability. Finally, the review also discussed the challenges and prospects of CSMNs' development. This review is expected to provide CSMNs' development roadmap in the context of 21st-century demands for biomedical therapeutics. |
| URI: | https://pubmed.ncbi.nlm.nih.gov/34119125/ http://archive.cmb.ac.lk:8080/xmlui/handle/70130/6060 |
| Appears in Collections: | Department of Chemistry |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| CellulosesupportedmagneticnanohybridsSynthesisphysicomagneticpropertiesandbiomedicalapplications-Areview.pdf | 8.7 MB | Adobe PDF | View/Open |
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