Please use this identifier to cite or link to this item: http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5561
Full metadata record
DC FieldValueLanguage
dc.contributor.authorPerera, Nandika-
dc.contributor.authorGalhena, G.-
dc.contributor.authorRanawaka, Gaya-
dc.date.accessioned2021-07-29T08:27:10Z-
dc.date.available2021-07-29T08:27:10Z-
dc.date.issued2021-
dc.identifier.citationPerera, K L & Galhena, Gayani & Ranawaka, Gaya. (2021). X-chromosomal STR based genetic polymorphisms and demographic history of Sri Lankan ethnicities and their relationship with global populations. Scientific Reports. 11. 10.1038/s41598-021-92314-9.en_US
dc.identifier.uriDOI:10.1038/s41598-021-92314-9-
dc.identifier.urihttp://archive.cmb.ac.lk:8080/xmlui/handle/70130/5561-
dc.description.abstractnew 16 X-short tandem repeat (STR) multiplex PCR system has recently been developed for Sr Lankans, though its applicability in evolutionary genetics and forensic investigations has not been thoroughly assessed. In this study, 838 unrelated individuals covering all four major ethnic groups (Sinhalese, Sri Lankan Tamils, Indian Tamils and Moors) in Sri Lanka were successfully genotyped using this new multiplex system. The results indicated a high forensic efficiency for the tested loci in all four ethnicities confirming its suitability for forensic applications of Sri Lankans. Allele frequency distribution of Indian Tamils showed subtle but statistically significant differences from those of Sinhalese and Moors, in contrast to frequency distributions previously reported for autosomal STR alleles. This suggest a sex biased demographic history among Sri Lankans requiring a separate X-STR allele frequency database for Indian Tamils. Substantial differences observed in the patterns of LD among the four groups demand the use of a separate haplotype frequency databases for each individual ethnicity. When analysed together with other 14 world populations, all Sri Lankan ethnicities except Indian Tamils clustered closely with populations from Indian Bhil tribe, Bangladesh and Europe reflecting their shared Indo-Aryan ancestry.en_US
dc.language.isoenen_US
dc.titleX‑chromosomal STR based genetic polymorphisms and demographic history of Sri Lankan ethnicities and their relationship with global populationsen_US
dc.typeArticleen_US
Appears in Collections:Department of Zoology

Files in This Item:
File Description SizeFormat 
X-chromosomal_STR_based_genetic_polymorphisms_and_.pdf995.44 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.