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|Title:||Graphene OxideeBased Nanocomposite for Sustained Release of Cephalexin|
|Authors:||Katuwavila, Nuwanthi P.|
Perera, Inoka C.
Amaratunga, Gehan A.J.
|Keywords:||graphene, drug delivery system(s), nanodrug(s), nanomedicine, nanocomposite(s), nanoparticle(s), nanotechnology, multidrug resistance, controlled release, drug resistance|
|Citation:||Nuwanthi P. Katuwavila, Yasuri Amarasekara, Vimukthi Jayaweera, Chamil Rajaphaksha, Chinthika Gunasekara, Inoka C. Perera, Gehan A.J. Amaratunga, Laksiri Weerasinghe, Graphene Oxideâ€“Based Nanocomposite for Sustained Release of Cephalexin, Journal of Pharmaceutical Sciences, Volume 109, Issue 2, 2020, Pages 1130-1135, ISSN 0022-3549, https://doi.org/10.1016/j.xphs.2019.09.022. (https://www.sciencedirect.com/science/article/pii/S002235491930629X)|
|Abstract:||A sustained-release carrier system for the drug cephalexin (CEF) using functionalized graphene oxide is reported. PEGylation of GO (GO-PEG) and successful loading of CEF into PEGylated graphene oxide (GO-PEG-CEF) nanoconjugate are confirmed by Fourier transform infrared spectroscopy, Raman spectroscopy, and thermogravimetric analysis. Encapsulation efficiency of 69% and a loading capacity of 19% are obtained with the optimized formulation of GO-PEG-CEF. In vitro CEF release profiles show an initial burst release followed by a more sustained release over a 96 h period with cumulative release of 80%. The half maximal inhibitory concentration (IC50) values have both dose- and time-dependent antibacterial activity for GO-PEG-CEF against both gram-positive and gram-negative bacteria while pure CEF showed only dose-dependent antibacterial activity. The minimum inhibitory concentration values of GO-PEG-CEF are 7.8 and 3.9 μg/mL against S. aureus and B. cereus, respectively, while it is 10 μg/mL with pure CEF against both gram-positive bacteria. This confirms the enhanced antibacterial activity of GO-PEG-CEF over pure CEF against gram-positive bacteria. These findings therefore show GO-PEG-CEF is promising as a sustained-release nanoantibiotic system for effective treatment against S. aureus and B. cereus infections.|
|Appears in Collections:||Department of Zoology|
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