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dc.contributor.authorDissanayake, Upadari-
dc.contributor.authorDias, Sajani-
dc.contributor.authorPolson, Hannah-
dc.contributor.authorLongacre, Shirley-
dc.contributor.authorUdagama-Randeniya, Preethi V-
dc.description.abstractNatural antibody (IgG + IgM) responses to putative vaccine candidate, Plasmodium vivax Merozoite Surface Protein-4, in acute vivax malaria patients in endemic and non-endemic areas of Sri Lanka, were assayed by indirect ELISA using PvMSP-4 baculovirus derived recombinant protein. The study populations were from two vivax malaria endemic areas, Anuradhapura and Kataragama and from a nonendemic area, Colombo. PvMSP4 appeared to be immunogenic in all test populations with a prevalence of 80%, 62% and 62% from Colombo, Anuradhapura and Kataragama, respectively. A significantly higher prevalence and antibody magnitude was recorded for non-endemic Colombo, but with no significant differences between individuals previously not exposed to malaria and those with prior exposure. A positive trend in responders from Kataragama was evident between the antibody prevalence and previous exposure. We previously reported the antibody response to PvMSP-1 (p19 and p42) using the same battery of sera, and when comparisons were drawn, more than 80% from each test area responded to at least one of the three antigens tested. Importantly, 7%, 11% and 4% of individuals from Colombo, Anuradhapura, and Kataragama, respectively, preferentially recognized PvMSP-4. Responders to MSP-1p42 and p19 in paired combination showed higher prevalence compared with combinations of MSP-1 with MSP-4.en_US
dc.description.sponsorshipFinancial assistance from the National Science Foundation, Sri Lanka (NSF/RG/2005/HS/06) and the Institute of Biochemistry Molecular Biology and Biotechnology, University of Colomboen_US
dc.publisherCeylon Journal of Science (Bio Science)en_US
dc.subjectPlasmodium vivaxen_US
dc.subjectSri Lankaen_US
dc.subjectmerozoite surface protein-4en_US
dc.titleImmunoepidemiology of Plasmodium vivax Merozoite Surface Protein-4 (PVMSP-4) in Sri Lanka: A Preliminary Studyen_US
Appears in Collections:Department of Zoology

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