Please use this identifier to cite or link to this item: http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5238
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dc.contributor.authorGunasekera, Anusha M.-
dc.contributor.authorWickramarachchi, Thilan-
dc.contributor.authorNeafsey, Daniel E.-
dc.contributor.authorGanguli, Ishani-
dc.contributor.authorPerera, Lakshman-
dc.contributor.authorPremaratne, Prasad H.-
dc.contributor.authorHartl, Daniel-
dc.contributor.authorHandunnetti, Shiroma M.-
dc.contributor.authorUdagama-Randeniya, Preethi V.-
dc.contributor.authorWirth, Dyann F.-
dc.date.accessioned2021-06-05T10:16:14Z-
dc.date.available2021-06-05T10:16:14Z-
dc.date.issued2007-
dc.identifier.citation74en_US
dc.identifier.otherhttps://doi.org/10.1093/molbev/msm013-
dc.identifier.urihttp://archive.cmb.ac.lk:8080/xmlui/handle/70130/5238-
dc.description.abstractPlasmodium vivax apical membrane antigen 1 (PvAMA-1) is an important malaria vaccine candidate. We present the first comprehensive analysis of nucleotide diversity across the entire PvAMA-1 gene using a single population sample from Sri Lanka. In contrast to what has been observed at the AMA-1 locus of Plasmodium falciparum, the signature of diversifying selection is seen most strongly in Domain II of PvAMA-1, indicating that the different domains in each species may be subject to varying selective pressures and functional constraints. We also find that recombination plays an important role in generating haplotype diversity at this locus, even in a region of low endemicity such as Sri Lanka. Mapping of diversity and recombination hotspots onto a 3-dimensional structural model of the protein indicates that one surface of the molecule may be particularly likely to bear epitopes for antibody recognition. Regions of this surface that show constrained variability may prove to be promising vaccine targets.en_US
dc.description.sponsorshipThe work was funded by the 2004 Burroughs Wellcome Fund–Ellison Medical Foundation–American SocietyofTropicalMedicineandHygienePostdoctoralFellowship awarded to A.M.G.; by an Ellison Senior Scholar AwardtoD.F.W.;andalsobytheHarvardMalariaInitiative, the Burroughs Wellcome Fund, and the Ellison Medical Foundation, Program in Career Development, Research and Training in Global Infectious Diseases. T.W. was supported by the National Science Foundation, Sri Lanka.en_US
dc.language.isoenen_US
dc.publisherMolecular Biology and Evolutionen_US
dc.subjectSelectionen_US
dc.subjectPlasmodium vivaxen_US
dc.subjectgenetic diversityen_US
dc.subjectrecombinationen_US
dc.titleGenetic Diversity and Selection at the Plasmodium vivax Apical Membrane Antigen-1 (PvAMA-1) Locus in a Sri Lankan Populationen_US
dc.typeArticleen_US
Appears in Collections:Department of Zoology

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