Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorUdagama, Preethi V.-
dc.contributor.authorGamage Mendis, Asoka C-
dc.contributor.authorDavid, Peter H.-
dc.contributor.authorPeiris, J.S.M.-
dc.contributor.authorPerera, K.L.R.L.-
dc.contributor.authorMendis, Kamini N.-
dc.contributor.authorCarter, Richard-
dc.description.abstractMonoclonal antibodies against variant epitopes of a highly polymorphic protein (PV200) in schizonts of Plasmodium vivax have been used to analyze the variety of genetically distinct populations of parasites present in the peripheral blood of individual P. vivax infections in Sri Lanka. In 9 out of 10 isolates of freshly drawn P. vivax infected blood from different individuals, parasites of only 1 PV200 serotype was found within each individual infection, even though parasites were serotypically distinct between individuals. In 1 isolate parasite population, 3 distinct PV200 serotypes were identified. Thus, most P. vivax infections appeared to consist of a single genetically homogeneous population of parasites within the detection limits of the technique. The prevalence of P. vivax infections in an area of malaria transmission in southern Sri Lanka and the densities of oocysts in mosquitoes fed on P. vivax infected individuals indicated that parasite populations would be transmitted many times before encountering parasites of other origins, and that individual populations would tend to reduce to genetic homogeneity during transmission. These expectations are consistent with the high proportion of genetically homogeneous P. vivax isolates observed.en_US
dc.description.sponsorshipUNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases and the British Medical Research Council.en_US
dc.publisherThe American journal of Tropical medicine and hygieneen_US
dc.subjectgenetic complexityen_US
dc.subjectPlasmodium vivaxen_US
dc.subjectmonoclonal antibodiesen_US
dc.titleGenetic complexity of Plasmodium vivax parasites in individual human infections analyzed with monoclonal antibodies against variant epitopes on a single parasite proteinen_US
Appears in Collections:Department of Zoology

Files in This Item:
File Description SizeFormat 
5.pdf5.33 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.