Please use this identifier to cite or link to this item: http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5211
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dc.contributor.authorMalik Peiris, J.S.-
dc.contributor.authorPremawansa, Sunil-
dc.contributor.authorRanawaka, Maya B.R-
dc.contributor.authorUdagama, Preethi V-
dc.contributor.authorMunasinghe, Yamuna D-
dc.contributor.authorNanayakkara, Manjula V-
dc.contributor.authorGamage, C Priyantha-
dc.contributor.authorCarter, Richard-
dc.contributor.authorDavid, Peter H-
dc.contributor.authorMendis, Kamini N-
dc.date.accessioned2021-05-23T12:37:06Z-
dc.date.available2021-05-23T12:37:06Z-
dc.date.issued1988-
dc.identifier.citation89en_US
dc.identifier.issn0002-9637-
dc.identifier.otherDOI: https://doi.org/10.4269/ajtmh.1988.39.26-
dc.identifier.urihttp://archive.cmb.ac.lk:8080/xmlui/handle/70130/5211-
dc.description.abstractAntibodies against gametes of the malarial parasite inhibit the development of the parasite in the mosquito and curtail the transmission of malaria. We now report that a monoclonal antibody against gametes of the human malaria pathogen Plasmodium vivax and antibodies induced during natural infections of P. vivax inhumans which suppress infectivity ofthe parasites to the vector at high concentrations can, at lower concentrations, have the opposite effect and enhance the level of malaria infection in the mosquitoes. Infectivity enhancing effects of up to l2-fold were demonstrated when a transmission blocking monoclonal antibody and immune human sera were diluted, in some undiluted immune human sera, and in the sera of vivax malaria patients during convalescence after drug cure.en_US
dc.description.sponsorshipThis investigation received support from the UNDP/World BanVWHO Special Programme for Research and Training in Tropical Diseases.en_US
dc.language.isoenen_US
dc.publisherThe American Society of Tropical Medicine and Hygieneen_US
dc.subjectMalariaen_US
dc.subjectPlasmodiumen_US
dc.subjectantibodiesen_US
dc.subjectParasiteen_US
dc.titleMonoclonal and polyclonal antibodies both block and enhance transmission of human Plasmodium vivax Malariaen_US
dc.typeArticleen_US
Appears in Collections:Department of Zoology

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