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Title: Monoclonal and polyclonal antibodies both block and enhance transmission of human Plasmodium vivax Malaria
Authors: Malik Peiris, J.S.
Premawansa, Sunil
Ranawaka, Maya B.R
Udagama, Preethi V
Munasinghe, Yamuna D
Nanayakkara, Manjula V
Gamage, C Priyantha
Carter, Richard
David, Peter H
Mendis, Kamini N
Keywords: Malaria
Issue Date: 1988
Publisher: The American Society of Tropical Medicine and Hygiene
Citation: 89
Abstract: Antibodies against gametes of the malarial parasite inhibit the development of the parasite in the mosquito and curtail the transmission of malaria. We now report that a monoclonal antibody against gametes of the human malaria pathogen Plasmodium vivax and antibodies induced during natural infections of P. vivax inhumans which suppress infectivity ofthe parasites to the vector at high concentrations can, at lower concentrations, have the opposite effect and enhance the level of malaria infection in the mosquitoes. Infectivity enhancing effects of up to l2-fold were demonstrated when a transmission blocking monoclonal antibody and immune human sera were diluted, in some undiluted immune human sera, and in the sera of vivax malaria patients during convalescence after drug cure.
ISSN: 0002-9637
Appears in Collections:Department of Zoology

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