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Title: | Effectiveness of Low-dose Ethinylestradiol/Cyproterone Acetate and Ethinylestradiol/Desogestrel with and without Metformin on Hirsutism in Polycystic Ovary Syndrome |
Other Titles: | A Randomized, Double-blind, Triple-dummy Study. |
Authors: | Fonseka, Sanjeewani Wijeyaratne, Chandrika N Gawarammana, Indika B Kalupahana, Nishan Rosairo, Shanthini Ratnatunga, Neelakanthi Kumarasiri, Ranjith |
Keywords: | Ferriman-Gallwey score Hirsutism cyproterone acetate desogestrel hair density hair diameter hair growth rate metformin polycystic ovary syndrome |
Issue Date: | 2020 |
Publisher: | Edgemont, PA : Matrix Medical Communications |
Citation: | Fonseka S, Wijeyaratne CN, Gawarammana IB, Kalupahana NS, Rosairo S, Ratnatunga N, Kumarasiri R. Effectiveness of Low-dose Ethinylestradiol/Cyproterone Acetate and Ethinylestradiol/Desogestrel with and without Metformin on Hirsutism in Polycystic Ovary Syndrome: A Randomized, Double-blind, Triple-dummy Study. J Clin Aesthet Dermatol. 2020 Jul;13(7):18-23. Epub 2020 Jul 1. |
Abstract: | BACKGROUND: The effectiveness of different combined oral contraceptive pills and metformin in reducing hirsutism in patients with polycystic ovary syndrome (PCOS) remains unclear. OBJECTIVE: We sought to determine the effects of ethinylestradiol (35μg)/cyproterone acetate (2mg) (EE/CPA) and ethinylestradiol (20μg)/desogestrel (0.15mg) (EE/DES), alone or with metformin, on hirsutism in PCOS. METHODS: A randomized, double-blind, triple-dummy study was conducted on women with PCOS and hirsutism (N=107) who received one of four drug combinations (Arm A: EE/CPA; Arm B: EE/DES; Arm C: EE/CPA plus metformin; or Arm D: EE/DES plus metformin). Hirsutism was assessed at baseline, six months, and 12 months by using five outcomes variables. RESULTS: No outcomes variable showed a significant difference between the four arms at 12 months. There was a significant reduction in both hair density and modified Ferriman-Gallwey score (mFGS) in Arm A, mFGS in Arm B, hair density in Arm C, and diameter of sideburn hair in Arm D, respectively. Separately, there was a significant increase noted in the hair growth rate of chin and an improvement in patients' perceptions of hirsutism in all four study arms. CONCLUSION: EE/CPA and EE/DES were equally effective in improving hirsutism in PCOS, with no added benefit from low-dose metformin. Sri Lanka Clinical Trials Registry (http://www.slctr.lk) registration no. SLCTR/2015/007. Keywords: Ferriman-Gallwey score; Hirsutism; cyproterone acetate; desogestrel; hair density; hair diameter; hair growth rate; metformin; polycystic ovary syndrome. |
URI: | http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5074 |
Appears in Collections: | Department of Obstetrics & Gynaecology |
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File | Description | Size | Format | |
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jcad_13_7_18.pdf | 328.3 kB | Adobe PDF | View/Open |
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