Please use this identifier to cite or link to this item: http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5073
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dc.contributor.authorWijeyaratne, C N-
dc.date.accessioned2021-02-22T17:40:41Z-
dc.date.available2021-02-22T17:40:41Z-
dc.date.issued2016-
dc.identifier.citationWijeyaratne CN, Galappaththi S, Palipane E, Jayawardane D, Dodampahala SH, Tudawe MN, Gooneratne LV, de Silva R, Ratnayake D, Seneviratne SL. Pregnancy outcomes of antiphospholipid syndrome: In a low resource South Asian setting. Obstet Med. 2016 Jun;9(2):83-9. doi: 10.1177/1753495X16629300.en_US
dc.identifier.urihttp://archive.cmb.ac.lk:8080/xmlui/handle/70130/5073-
dc.description.abstractProblem: Antiphospholipid syndrome is associated with recurrent pregnancy loss, and specific treatment improves pregnancy outcome. Laboratory diagnosis is limited in South Asia. We assessed management outcomes of definite/probable antiphospholipid syndrome treated at a tertiary centre in Sri Lanka. Method: Descriptive cross-sectional study of pregnancy outcomes with heparin and aspirin therapy. Outcome measures: miscarriage, intrauterine death and live birth when compared to previous untreated pregnancies. Results: Of 646 gestations in 145 women, 146 (22.6%) received specific treatment. In the preceding pregnancies without specific treatment, the rates of miscarriage, late fetal loss, stillbirth and live birth were 60%, 26%, 8% and 7%, respectively. Following specific treatment with low-dose aspirin ± low-molecular-weight heparin in 146 pregnancies (145 women), the rates of miscarriage, late fetal loss, stillbirth and live birth were 14%, 10%, 3% and 74%, respectively. Mean birth weight was 2.54 ± 0.62 kg, preterm births complicated 32 (29.6%) with a mean gestational age at delivery 33.7 ± 2.6 weeks, with three neonatal deaths. Maternal complications were: pre-eclampsia 16 (10.9%), gestational diabetes 28 (19.2%), antepartum haemorrhage in 1 patient. Only 73/145 (50.3%) women had laboratory confirmation of antiphospholipid syndrome, while others were treated empirically. Live births in diagnosed vs. empiric treatment - 80.8% vs. 67.1%. Conclusion: Pregnant women with clinical antiphospholipid syndrome when treated with low-dose aspirin and heparin, the live birth rate of 7% in the previous pregnancy resulted in live births of 74% in a resource-limited South Asian setting.en_US
dc.language.isoenen_US
dc.publisherLondon : Royal Society of Medicine Pressen_US
dc.subjectHeparinen_US
dc.subjectSri Lankaen_US
dc.subjectlow-dose aspirinen_US
dc.subjectrecurrent pregnancy lossen_US
dc.titlePregnancy outcomes of antiphospholipid syndrome: In a low resource South Asian settingen_US
dc.typeArticleen_US
Appears in Collections:Department of Obstetrics & Gynaecology

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