Please use this identifier to cite or link to this item: http://archive.cmb.ac.lk:8080/xmlui/handle/70130/2111
Full metadata record
DC FieldValueLanguage
dc.contributor.authorDayananda, P.D.
dc.contributor.authorYapa, W.B.
dc.contributor.authorRatnasooriya, W.D.
dc.date.accessioned2012-03-05T03:02:51Z
dc.date.available2012-03-05T03:02:51Z
dc.date.issued2012
dc.identifier.citationPhamacognosy Magazineen_US
dc.identifier.urihttp://archive.cmb.ac.lk:8080/xmlui/handle/70130/2111-
dc.description.abstractThis study examined the blood glucose lowering potential of the aqueous stem bark extract (ABE) of Sri Lankan endemic plant - Kokoona zeylanica (Family: Celestraceae). This was tested in normoglycaemic mice using three oral doses (1800, 2500 and 3000 mg/kg of body weight). The results show a moderate but dose dependant acute hypoglycaemic activity with a fairly rapid onset (4 h). However, It did not have a hypoglycaemic effect in non fasted mice or in fasted mice (treated consecutively for 30 days). ABE did not improve the glucose tolerance test indicating the Lack of antihyperglycaemic activity. However, ABE improved the sucrose tolerance test indicating the a-glucosidase inhibitory activity, which appears to be the main mechanism of hypoglycaemic activity. ABE was well tolerated {in terms of overt clinical signs of toxicity, hepatotoxicity and renotoxicity), and it did not provoke a change in the lipid profile. It is concluded that the ABE of K. zeylanica has a safe, moderate and acute hypoglycaemic activity
dc.language.isoenen_US
dc.titleThe effect of the aqueous stem bark extract of Kokoona zeylamca Thw. on the blood glucose level of miceen_US
dc.typeJournal abstracten_US
Appears in Collections:Department of Zoology

Files in This Item:
File Description SizeFormat 
profR031.pdf336.51 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.