Please use this identifier to cite or link to this item: http://archive.cmb.ac.lk:8080/xmlui/handle/70130/2110
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dc.contributor.authorPATHIRANA, W.
dc.contributor.authorABHAYAWARDHANA, P.
dc.contributor.authorKARIYAWASAM, H.
dc.contributor.authorRATNASOORIYA, W. D.
dc.date.accessioned2012-03-05T02:59:14Z
dc.date.available2012-03-05T02:59:14Z
dc.date.issued2009
dc.identifier.citationIndian Journal of Pharmaceutical Sciences, Vol. 71, Issue 3, May-June 2009en_US
dc.identifier.urihttp://archive.cmb.ac.lk:8080/xmlui/handle/70130/2110-
dc.description.abstractThe unique anatomical arrangement of blood vessels and sinuses in the human skull and the brain, the prevalence of a high density of skin appendages in the scalp, extracranial vessels of the scalp communicating with the brain via emissary veins and most importantly, the way that the scalp is used in Ayurvedic medical system in treating diseases associated with the brain show that a drug could be transcranlaUy delivered targeted to the brain through the scalp. The present study was to investigate by measuring the antinociceptive effect on rats whether the opioid analgesic methadone could be delivered targeted to the brain by transcranial delivery route. A non aqueous solution of methadone base in sesame oil was used for the application on the scalp. Animal studies were carried out using six groups of male rats consisting of group 1, the oral control treated with distilled water I mi; group 2, the oral positive control tr^ted with methadone hydrochloride solution 316.5 pg/ml; group 3, the negative control treated transctanially with the blank sesame oil 0.2 ml and three test groups 4, 5 and 6 treated with three different dose levels of the transcranial oil formulation of methadone base, 41.6 pg/0.2 ml, 104 pg/0.2 ml and 208 }ig/0.2 ml, respectively. The antinociceptive effects were examined by subjecting the rats to the hot plate and tail flick tests. The two higher concentrations of the three transcranial methadone formulations yielded response vs rime curves showing nearly equal maximimi antinociceprive effects similar to that of the oral positive control. Maximiun analgesic effect after transcranial admirustrarion was observed between 1st and 2nd h and declined up to 6th hour. The results indicate that the transcranial brain targeted delivery of methadone base in the form of an oil based non aqueous solurion results in statistically significant antinociceptive effects under experimental conditions. Therefore, it is possible to deliver central nervous system drugs through tlie proposed transcranial route when suitably formulated.
dc.language.isoenen_US
dc.titleTranscranial Route of Brain Targeted Delivery of Methadone in Oilen_US
dc.typeJournal abstracten_US
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