Please use this identifier to cite or link to this item: http://archive.cmb.ac.lk:8080/xmlui/handle/70130/2006
Full metadata record
DC FieldValueLanguage
dc.contributor.authorDissanayake, V.H.W.-
dc.contributor.authorTower, C.-
dc.contributor.authorBroderick, A.-
dc.contributor.authorStocker, L.J.-
dc.contributor.authorSeneviratne, H.R.-
dc.contributor.authorJayasekara, R.W.-
dc.contributor.authorKalsheker, N.-
dc.contributor.authorPipkin, F.B.-
dc.contributor.authorMorgan, L.-
dc.date.accessioned2012-02-29T06:04:11Z-
dc.date.available2012-02-29T06:04:11Z-
dc.date.issued2007-
dc.identifier.citationMolecular Human Reproduction Volume 13, Issue 6, June 2007, Pages 425-429en_US
dc.identifier.urihttp://archive.cmb.ac.lk:8080/xmlui/handle/70130/2006-
dc.description.abstractBirthweight predicts health later in life and is influenced by inherited factors. We investigated the association of the c.61G > A, and c.2566G > A polymorphisms in the epidermal growth factor (EGF) gene [GenBank NM_01963] with birthweight in three groups of healthy pregnant women, and in women with pregnancies affected by fetal growth restriction (FGR). Subjects comprised 171 Sinhalese women with normal pregnancies (Group A), 64 white Western European women with normal pregnancies (Group B), 101 white Western European women with normal pregnancies and their babies (Group C) and 107 women with pregnancies affected by FGR, their partners and their babies (Group D). Maternal EGF genotypes were associated with birthweight of healthy babies of women in Groups A (P = 0.03), B (P = 0.001) and C (P = 0.01). The association persisted following adjustment for confounding by gestational age, sex, maternal weight, parity and smoking habit. The trend from heaviest to lightest birthweights in all these groups was c.61AA > c.61GA > c.61GG and c.2566GG > c.2566GA > c.2566AA. The EGF haplotype associated with lower birthweight (c.61G, c.2566A) was transmitted at increased frequency from heterozygous parents to babies affected by FGR in Group D (P = 0.02). These findings support the hypothesis that growth factors expressed by the feto-maternal unit affect birthweight, and implicates polymorphism in the EGF gene in the aetiology of birthweight variability. © The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology.en_US
dc.language.isoenen_US
dc.titlePolymorphism in the epidermal growth factor gene is associated with birthweight in Sinhalese and white Western Europeansen_US
dc.typeJournal abstracten_US
Appears in Collections:Department of Anatomy

Files in This Item:
File Description SizeFormat 
7.pdf13.55 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.