Please use this identifier to cite or link to this item: http://archive.cmb.ac.lk:8080/xmlui/handle/70130/1330
Title: Randamized study of Neo-adjuvant combination Chemotherapy and Radiotherapy Vs Radiotherapy alone in advanced stage Oral and Oropharyngeal Squamous Cell Carcinoma.
Authors: Sinnathamby, K
Issue Date: 1996
Citation: MD (Radiotherapy and Oncology)
Abstract: This randomized trial was undertaken to test the influence of neo-adjuvant chemotherapy on the local control of advanced carcinoma of oral cavity and oropharynx,when given with radiotherapy.In this trial cis-platin based combination chemotherapy and radiotheraphy arm was tested against radiation only arm.24 patient were enrolled into this randomized trial.The patients were randomized by assigning them alternatively to either arms.Inclusion criteria were histologically proven squamous cell carcinoma of oral cavity or oropharynx,stage T3/T4 or N2/N3 disease,performance status of 2 or less and normal renal function test and normal WBC/DC count.All patients with the lesions in the oropharynx and some patient with lesions in the oral cavity presented to our institute with histologically confirmed squamous cell carcinoma.In others histological cofiramation was obtained using a punch biopsy specimen.All patients except one completed scheduled therapy without any interruption or alteration in the treatment schedule.The one who had not competed the schedule thetapy was lost following chemotherapy.Remaining all 23 patients were followedup until 3 months after completion of treatment for the purpose of this study
URI: http://archive.cmb.ac.lk:8080/xmlui/handle/70130/1330
Appears in Collections:Masters Theses - Postgraduate Institute of Medicine

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